Phenoxypropazine

CHEMBL1909286 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

166.2 g/mol

LogP

1.1

Phase

4

Phenoxypropazine is a monoamine oxidase inhibitor (MAOI) that irreversibly inhibits both MAO-A and MAO-B enzymes, thereby increasing synaptic concentrations of serotonin, norepinephrine, and dopamine. It was investigated as an antidepressant but was largely supplanted by safer antidepressant classes due to its significant food and drug interaction profile.

Masse moléculaire

166,2200 g/mol

LogP

1,10

TPSA

47,30 Å²

Règle des 5 de Lipinski

Conforme

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

CC(COc1ccccc1)NN

InChI

InChI=1S/C9H14N2O/c1-8(11-10)7-12-9-5-3-2-4-6-9/h2-6,8,11H,7,10H2,1H3

Molecular Formula

C9H14N2O

HBD / HBA

2 / 3

Liaisons Rotatives

4

Atomes Lourds

12

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

Phenoxypropazine is a monoamine oxidase inhibitor (MAOI) that irreversibly inhibits both MAO-A and MAO-B enzymes, thereby increasing synaptic concentrations of serotonin, norepinephrine, and dopamine. It was investigated as an antidepressant but was largely supplanted by safer antidepressant classes due to its significant food and drug interaction profile.

Yes, Phenoxypropazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1909286. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 71467. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Données Clés

Formule: C9H14N2O

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.