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Propoxyphene

CHEMBL1213351 Phase 4 Approuvé Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
339.5 g/mol
LogP
4.2
Phase
4

Propoxyphene is a synthetic opioid analgesic of the diphenylheptane class that acts primarily as a mu-opioid receptor agonist to produce analgesia, sedation, and euphoria, with potency approximately half that of codeine. It was used for mild to moderate pain management but was withdrawn globally due to its cardiac toxicity, particularly QT prolongation and potentially fatal arrhythmias even at therapeutic doses.

Masse moléculaire

339,5000 g/mol

LogP

4,20

TPSA

29,50 Ų

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Pain Management Chronic Pain

Mécanisme d'action

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mécanisme

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

Structure 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCC(=O)O[C@](Cc1ccccc1)(c1ccccc1)[C@H](C)CN(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C22H29NO2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19/h6-15,18H,5,16-17H2,1-4H3/t18-,22+/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H29NO2

                    

                    
                    

                        
HBD / HBA

                        
- / 3

                    

                    
                    

                        
Liaisons Rotatives

                        
9

                    

                    
                    
                    

                        
Atomes Lourds

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Foire aux questions

                

                    
                    

                        
                        

                            
Propoxyphene is a synthetic opioid analgesic of the diphenylheptane class that acts primarily as a mu-opioid receptor agonist to produce analgesia, sedation, and euphoria, with potency approximately half that of codeine. It was used for mild to moderate pain management but was withdrawn globally due to its cardiac toxicity, particularly QT prolongation and potentially fatal arrhythmias even at therapeutic doses.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Propoxyphene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1213351.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 10100.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Avertissement médical

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.