Propoxyphene
Propoxyphene is a synthetic opioid analgesic of the diphenylheptane class that acts primarily as a mu-opioid receptor agonist to produce analgesia, sedation, and euphoria, with potency approximately half that of codeine. It was used for mild to moderate pain management but was withdrawn globally due to its cardiac toxicity, particularly QT prolongation and potentially fatal arrhythmias even at therapeutic doses.
Moleküler Ağırlık
339,5000 g/mol
LogP
4,20
TPSA
29,50 Ų
Lipinski RO5
Geçer
Terapötik Alanlar
Etki Mekanizması
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
2D Yapı
Cite this structure
Embed this structure
SMILES
CCC(=O)O[C@](Cc1ccccc1)(c1ccccc1)[C@H](C)CN(C)C
InChI
InChI=1S/C22H29NO2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19/h6-15,18H,5,16-17H2,1-4H3/t18-,22+/m1/s1
Molecular Formula
C22H29NO2
HBD / HBA
- / 3
Döndürülebilir Bağlar
9
Ağır Atomlar
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
Propoxyphene is a synthetic opioid analgesic of the diphenylheptane class that acts primarily as a mu-opioid receptor agonist to produce analgesia, sedation, and euphoria, with potency approximately half that of codeine. It was used for mild to moderate pain management but was withdrawn globally due to its cardiac toxicity, particularly QT prolongation and potentially fatal arrhythmias even at therapeutic doses.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Propoxyphene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1213351. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 10100. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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