Sulfamerazine

CHEMBL438 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

264.3 g/mol

LogP

0.1

Phase

4

Sulfamerazine is an intermediate-acting sulfonamide antibiotic used in combination with other sulfonamides (trisulfapyrimidines) for the treatment of urinary tract infections, nocardiosis, and other susceptible bacterial infections. Combination sulfonamide therapy reduces the risk of crystalluria by lowering the individual concentration of each sulfonamide while maintaining antibacterial activity. Like all sulfonamides, it inhibits dihydropteroate synthase in susceptible bacteria.

Masse moléculaire

264,3100 g/mol

LogP

0,10

TPSA

106,00 Å²

Règle des 5 de Lipinski

Conforme

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1

InChI

InChI=1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)

Molecular Formula

C11H12N4O2S

HBD / HBA

2 / 6

Liaisons Rotatives

3

Atomes Lourds

18

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

Sulfamerazine is an intermediate-acting sulfonamide antibiotic used in combination with other sulfonamides (trisulfapyrimidines) for the treatment of urinary tract infections, nocardiosis, and other susceptible bacterial infections. Combination sulfonamide therapy reduces the risk of crystalluria by lowering the individual concentration of each sulfonamide while maintaining antibacterial activity. Like all sulfonamides, it inhibits dihydropteroate synthase in susceptible bacteria.

Yes, Sulfamerazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL438. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5325. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Données Clés

Formule: C11H12N4O2S
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.