Sulfamerazine
Sulfamerazine is an intermediate-acting sulfonamide antibiotic used in combination with other sulfonamides (trisulfapyrimidines) for the treatment of urinary tract infections, nocardiosis, and other susceptible bacterial infections. Combination sulfonamide therapy reduces the risk of crystalluria by lowering the individual concentration of each sulfonamide while maintaining antibacterial activity. Like all sulfonamides, it inhibits dihydropteroate synthase in susceptible bacteria.
分子量
264.3100 g/mol
LogP
0.10
TPSA
106.00 Ų
Lipinski 五规则
符合
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1
InChI
InChI=1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
Molecular Formula
C11H12N4O2S
HBD / HBA
2 / 6
可旋转键数
3
重原子数
18
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Sulfamerazine is an intermediate-acting sulfonamide antibiotic used in combination with other sulfonamides (trisulfapyrimidines) for the treatment of urinary tract infections, nocardiosis, and other susceptible bacterial infections. Combination sulfonamide therapy reduces the risk of crystalluria by lowering the individual concentration of each sulfonamide while maintaining antibacterial activity. Like all sulfonamides, it inhibits dihydropteroate synthase in susceptible bacteria.
Yes, Sulfamerazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL438. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5325. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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