Tetrahydrozoline

CHEMBL1266 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

200.3 g/mol

LogP

1.8

Phase

4

Tetrahydrozoline is a direct-acting sympathomimetic alpha-adrenergic agonist that causes vasoconstriction of conjunctival and nasal blood vessels by stimulating α1 and α2 receptors, producing rapid reduction of redness and congestion. It is available over-the-counter as ophthalmic drops for eye redness and as nasal drops/sprays for temporary nasal decongestion. Prolonged use can lead to rebound congestion (rhinitis medicamentosa) due to down-regulation of adrenergic receptors.

Masse moléculaire

200,2800 g/mol

LogP

1,80

TPSA

24,40 Å²

Règle des 5 de Lipinski

Conforme

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

c1ccc2c(c1)CCCC2C1=NCCN1

InChI

InChI=1S/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15)

Molecular Formula

C13H16N2

HBD / HBA

1 / 1

Liaisons Rotatives

1

Atomes Lourds

15

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

Tetrahydrozoline is a direct-acting sympathomimetic alpha-adrenergic agonist that causes vasoconstriction of conjunctival and nasal blood vessels by stimulating α1 and α2 receptors, producing rapid reduction of redness and congestion. It is available over-the-counter as ophthalmic drops for eye redness and as nasal drops/sprays for temporary nasal decongestion. Prolonged use can lead to rebound congestion (rhinitis medicamentosa) due to down-regulation of adrenergic receptors.

Yes, Tetrahydrozoline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1266. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5419. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Données Clés

Formule: C13H16N2
Synonymes: 149

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.