Triamterene

CHEMBL585 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

253.3 g/mol

LogP

1.0

Phase

4

This potassium-sparing diuretic helps the kidneys remove excess fluid from the body without causing the loss of potassium, and is used to treat fluid retention (edema) related to heart failure, liver disease, or kidney disease, often in combination with another diuretic. Unlike most diuretics that cause potassium loss, triamterene helps retain potassium, so potassium supplements or potassium-rich foods should be avoided. Kidney function and potassium levels need regular monitoring.

Masse moléculaire

253,2600 g/mol

LogP

1,00

TPSA

130,00 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Hypertension Cardiovascular Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1

InChI

InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

Molecular Formula

C12H11N7

HBD / HBA

3 / 7

Liaisons Rotatives

1

Atomes Lourds

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

This potassium-sparing diuretic helps the kidneys remove excess fluid from the body without causing the loss of potassium, and is used to treat fluid retention (edema) related to heart failure, liver disease, or kidney disease, often in combination with another diuretic. Unlike most diuretics that cause potassium loss, triamterene helps retain potassium, so potassium supplements or potassium-rich foods should be avoided. Kidney function and potassium levels need regular monitoring.

Yes, Triamterene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL585. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5546. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Données Clés

Formule: C12H11N7
Synonymes: 3

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.