Tribromsalan
Tribromsalan (TBS, 3,4,5-tribromosalicylanilide) is a halogenated salicylanilide with antibacterial and antifungal properties that disrupts microbial membrane integrity and inhibits enzyme systems through electrophilic reactivity. It was used as an antimicrobial ingredient in soaps and personal care products but was banned in the United States by the FDA due to photocontact sensitization causing photoallergic contact dermatitis and lack of proven clinical benefit over plain soap. It represents an early antimicrobial triclosan-related agent with unacceptable safety profile.
Masse moléculaire
449,9200 g/mol
LogP
5,00
TPSA
49,30 Ų
Règle des 5 de Lipinski
Conforme
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Structure 2D
Cite this structure
Embed this structure
SMILES
O=C(Nc1ccc(Br)cc1)c1cc(Br)cc(Br)c1O
InChI
InChI=1S/C13H8Br3NO2/c14-7-1-3-9(4-2-7)17-13(19)10-5-8(15)6-11(16)12(10)18/h1-6,18H,(H,17,19)
Molecular Formula
C13H8Br3NO2
HBD / HBA
2 / 2
Liaisons Rotatives
2
Atomes Lourds
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Tribromsalan (TBS, 3,4,5-tribromosalicylanilide) is a halogenated salicylanilide with antibacterial and antifungal properties that disrupts microbial membrane integrity and inhibits enzyme systems through electrophilic reactivity. It was used as an antimicrobial ingredient in soaps and personal care products but was banned in the United States by the FDA due to photocontact sensitization causing photoallergic contact dermatitis and lack of proven clinical benefit over plain soap. It represents an early antimicrobial triclosan-related agent with unacceptable safety profile.
Yes, Tribromsalan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL24944. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 14868. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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