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Thiethylperazine

CHEMBL1378 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
399.6 g/mol
LogP
5.4
Phase
4

Thiethylperazine is a phenothiazine antipsychotic with potent dopamine D2 receptor antagonist activity, used clinically as an antiemetic for the prevention and treatment of nausea and vomiting, including postoperative nausea and chemotherapy-induced emesis, through blockade of dopamine receptors in the chemoreceptor trigger zone. It also blocks muscarinic, histaminergic, and alpha-adrenergic receptors, contributing to its antiemetic efficacy and adverse effect profile. Its use has declined with the availability of more selective antiemetic agents.

आणविक भार

399.6000 g/mol

LogP

5.40

TPSA

60.30 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

दर्द प्रबंधन

क्रिया का तंत्र

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

तंत्र

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2

                

                

                
                

                    
InChI

                    
InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H29N3S2

                    

                    
                    

                        
HBD / HBA

                        
- / 5

                    

                    
                    

                        
घूर्णनीय बंधन

                        
6

                    

                    
                    
                    

                        
भारी परमाणु

                        
27

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
Thiethylperazine is a phenothiazine antipsychotic with potent dopamine D2 receptor antagonist activity, used clinically as an antiemetic for the prevention and treatment of nausea and vomiting, including postoperative nausea and chemotherapy-induced emesis, through blockade of dopamine receptors in the chemoreceptor trigger zone. It also blocks muscarinic, histaminergic, and alpha-adrenergic receptors, contributing to its antiemetic efficacy and adverse effect profile. Its use has declined with the availability of more selective antiemetic agents.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Thiethylperazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1378.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5440.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.