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Thiethylperazine

CHEMBL1378 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
399.6 g/mol
LogP
5.4
Phase
4

Thiethylperazine is a phenothiazine antipsychotic with potent dopamine D2 receptor antagonist activity, used clinically as an antiemetic for the prevention and treatment of nausea and vomiting, including postoperative nausea and chemotherapy-induced emesis, through blockade of dopamine receptors in the chemoreceptor trigger zone. It also blocks muscarinic, histaminergic, and alpha-adrenergic receptors, contributing to its antiemetic efficacy and adverse effect profile. Its use has declined with the availability of more selective antiemetic agents.

Khối lượng phân tử

399,6000 g/mol

LogP

5,40

TPSA

60,30 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Pain Management

Cơ chế tác dụng

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2

                

                

                
                

                    
InChI

                    
InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H29N3S2

                    

                    
                    

                        
HBD / HBA

                        
- / 5

                    

                    
                    

                        
Liên kết có thể quay

                        
6

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
27

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Thiethylperazine is a phenothiazine antipsychotic with potent dopamine D2 receptor antagonist activity, used clinically as an antiemetic for the prevention and treatment of nausea and vomiting, including postoperative nausea and chemotherapy-induced emesis, through blockade of dopamine receptors in the chemoreceptor trigger zone. It also blocks muscarinic, histaminergic, and alpha-adrenergic receptors, contributing to its antiemetic efficacy and adverse effect profile. Its use has declined with the availability of more selective antiemetic agents.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Thiethylperazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1378.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5440.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.