Narrow Therapeutic Index (NTI)
NTIA drug for which small changes in dose or blood concentration can lead to serious therapeutic failures or adverse effects. Requires careful dose titration, therapeutic drug monitoring, and bioequivalence scrutiny.
Contoh
- Warfarin
- Lithium
- Digoxin
- Phenytoin
- Cyclosporine
Tahukah Anda?
A drug for which small changes in dose or blood concentration can lead to serious therapeutic failures or adverse effects. Requires careful dose titration, therapeutic drug monitoring, and bioequivalence scrutiny.