Major
Established
Deskripsi
Pregabalin potentiates the respiratory depressant and sedative effects of morphine, creating a high-risk combination for overdose.
Mekanisme
Pregabalin binds alpha-2-delta calcium channel subunits, reducing excitatory neurotransmission; additive CNS depression occurs with opioid receptor activation.
Signifikansi Klinis
Post-marketing surveillance data show increased opioid-related overdose mortality when pregabalin is co-prescribed.
Penatalaksanaan
Use only when benefits outweigh risks; prescribe the lowest effective doses and instruct patients about respiratory depression warning signs.