HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
Fungsi
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
Obat yang Bekerja pada Target Ini
| Obat | Aksi | Utama |
|---|---|---|
| Atorvastatin | Inhibitor | Ya |
| Simvastatin | Inhibitor | Ya |
| Rosuvastatin | Inhibitor | Ya |
| Pravastatin | Inhibitor | Ya |