Acetaminophen
A widely used pain reliever and fever reducer that works in the brain and nervous system to raise the threshold for pain and lower elevated body temperature. It is available without a prescription for mild to moderate pain from headaches, muscle aches, and fever. Taking more than the recommended daily amount, or combining it with alcohol, can cause serious liver damage, so it is important to check all medications for acetaminophen content to avoid accidental overdose.
分子量
151.1630 g/mol
LogP
0.50
TPSA
49.30 Ų
リピンスキーの五則
適合
治療領域
薬物分類
作用機序
Inhibits prostaglandin synthesis in the CNS and peripherally blocks pain impulse generation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits prostaglandin synthesis in the CNS and peripherally blocks pain impulse generation.
2D構造
Cite this structure
Embed this structure
SMILES
CC(=O)Nc1ccc(O)cc1
InChI
InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
Molecular Formula
C8H9NO2
HBD / HBA
2 / 2
回転可能結合数
1
重原子数
11
Repeated acetaminophen use may modestly lower lamotrigine plasma levels through induction of UGT glucuronidation pathways, though the clinical impact is generally small.
Omeprazole can modestly increase the rate of acetaminophen absorption by altering gastric pH, but the effect on overall bioavailability and therapeutic outcome is not clinically meaningful under most circumstances.
Carbamazepine induces CYP enzymes that convert acetaminophen to its hepatotoxic metabolite NAPQI, increasing the risk of acetaminophen-induced liver injury even at therapeutic doses.
Regular or high-dose acetaminophen can potentiate the anticoagulant effect of warfarin, leading to INR elevation and increased bleeding risk, even though single analgesic doses carry a lower risk.
Phenytoin induces hepatic CYP enzymes that increase the formation of acetaminophen's toxic metabolite NAPQI, raising hepatotoxicity risk; conversely, large doses of acetaminophen may transiently reduce phenytoin levels.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A widely used pain reliever and fever reducer that works in the brain and nervous system to raise the threshold for pain and lower elevated body temperature. It is available without a prescription for mild to moderate pain from headaches, muscle aches, and fever. Taking more than the recommended daily amount, or combining it with alcohol, can cause serious liver damage, so it is important to check all medications for acetaminophen content to avoid accidental overdose.
Inhibits prostaglandin synthesis in the CNS and peripherally blocks pain impulse generation.
Key pharmacokinetic parameters for Acetaminophen: Half-life: 1-4 hours.
Yes, Acetaminophen is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL112. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 1983. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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