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Acetaminophen

CHEMBL112 Phase 4 Approuvé Small molecule
Half-Life
1-4 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
151.2 g/mol
LogP
0.5
Phase
4

A widely used pain reliever and fever reducer that works in the brain and nervous system to raise the threshold for pain and lower elevated body temperature. It is available without a prescription for mild to moderate pain from headaches, muscle aches, and fever. Taking more than the recommended daily amount, or combining it with alcohol, can cause serious liver damage, so it is important to check all medications for acetaminophen content to avoid accidental overdose.

Masse moléculaire

151,1630 g/mol

LogP

0,50

TPSA

49,30 Ų

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Benign Prostatic Hyperplasia Glaucoma Cardiovascular Disease Respiratory Disease Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Osteoporosis Asthma Alzheimer's Disease Parkinson's Disease Epilepsy Migraine Bipolar Disorder Generalized Anxiety Disorder Insomnia Melanoma Inflammatory Bowel Disease Psoriasis Systemic Lupus Erythematosus Multiple Sclerosis Non-Alcoholic Fatty Liver Disease Stroke Deep Vein Thrombosis / Pulmonary Embolism Obesity Lymphoma Type 2 Diabetes Hypertension Breast Cancer Chronic Pain Malaria HIV/AIDS Hepatitis C Tuberculosis Atrial Fibrillation Prostate Cancer Colorectal Cancer Leukemia

Classes de médicaments

N — N - Nervous System

Mécanisme d'action

Inhibits prostaglandin synthesis in the CNS and peripherally blocks pain impulse generation.

Pharmacokinetics (PK)

Half-Life 1-4 hours

Pharmacodynamics (PD)

Mécanisme

Inhibits prostaglandin synthesis in the CNS and peripherally blocks pain impulse generation.

Structure 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)Nc1ccc(O)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H9NO2

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
Liaisons Rotatives

                        
1

                    

                    
                    
                    

                        
Atomes Lourds

                        
11

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            PTGS2 (Cyclooxygenase-2)
                            Inhibitor
                        

                        
                        Primary Target
                        
                    

                    
                    

                        

                            PTGS1 (Cyclooxygenase-1)
                            Inhibitor
                        

                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Minor


                            
                                Acetaminophen + Lamotrigine
                            
                        

                        
                        
Repeated acetaminophen use may modestly lower lamotrigine plasma levels through induction of UGT glucuronidation pathways, though the clinical impact is generally small.

                        
                    
                    
                    
                        

                            

  
  Minor


                            
                                Acetaminophen + Omeprazole
                            
                        

                        
                        
Omeprazole can modestly increase the rate of acetaminophen absorption by altering gastric pH, but the effect on overall bioavailability and therapeutic outcome is not clinically meaningful under most circumstances.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Acetaminophen + Carbamazepine
                            
                        

                        
                        
Carbamazepine induces CYP enzymes that convert acetaminophen to its hepatotoxic metabolite NAPQI, increasing the risk of acetaminophen-induced liver injury even at therapeutic doses.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Acetaminophen + Warfarin
                            
                        

                        
                        
Regular or high-dose acetaminophen can potentiate the anticoagulant effect of warfarin, leading to INR elevation and increased bleeding risk, even though single analgesic doses carry a lower risk.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Acetaminophen + Phenytoin
                            
                        

                        
                        
Phenytoin induces hepatic CYP enzymes that increase the formation of acetaminophen's toxic metabolite NAPQI, raising hepatotoxicity risk; conversely, large doses of acetaminophen may transiently reduce phenytoin levels.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Foire aux questions

                

                    
                    

                        
                        

                            
A widely used pain reliever and fever reducer that works in the brain and nervous system to raise the threshold for pain and lower elevated body temperature. It is available without a prescription for mild to moderate pain from headaches, muscle aches, and fever. Taking more than the recommended daily amount, or combining it with alcohol, can cause serious liver damage, so it is important to check all medications for acetaminophen content to avoid accidental overdose.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits prostaglandin synthesis in the CNS and peripherally blocks pain impulse generation.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Acetaminophen: Half-life: 1-4 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Acetaminophen is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Aspirin
                            Small molecule
                        
                        
                        
                            Sertraline
                            Small molecule
                        
                        
                        
                            Escitalopram
                            Small molecule
                        
                        
                        
                            Fluoxetine
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL112.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 1983.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Avertissement médical

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.