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Alprazolam

CHEMBL661 Phase 4 承認済み Small molecule
Half-Life
6-12 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
308.8 g/mol
LogP
2.1
Phase
4

A benzodiazepine medication that enhances the effect of GABA, the brain's main inhibitory neurotransmitter, producing calming, anti-anxiety, and sedative effects. It is prescribed for generalized anxiety disorder, panic disorder, and anxiety associated with depression, though it carries risks of dependence and withdrawal with prolonged use.

分子量

308.7650 g/mol

LogP

2.10

TPSA

43.10 Ų

リピンスキーの五則

適合

治療領域

Pain Management Ophthalmology Asthma Alzheimer's Disease Epilepsy Migraine Schizophrenia Generalized Anxiety Disorder Type 2 Diabetes Chronic Pain

薬物分類

N — N - Nervous System

作用機序

High-potency benzodiazepine GABA-A receptor modulator.

Pharmacokinetics (PK)

Half-Life 6-12 hours

Pharmacodynamics (PD)

機序

High-potency benzodiazepine GABA-A receptor modulator.

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2

                

                

                
                

                    
InChI

                    
InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H13ClN4

                    

                    
                    

                        
HBD / HBA

                        
- / 3

                    

                    
                    

                        
回転可能結合数

                        
1

                    

                    
                    
                    

                        
重原子数

                        
22

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            GABRA1 (GABA-A Receptor)
                            Agonist
                        

                        
                        Primary Target
                        
                    

                    
                    

                        

                            CYP3A4 (Cytochrome P450 3A4)
                            Substrate
                        

                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Alprazolam + Zolpidem
                            
                        

                        
                        
Combining alprazolam with zolpidem produces additive CNS depression, profound sedation, psychomotor impairment, and respiratory depression risk.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Alprazolam + Oxycodone
                            
                        

                        
                        
The combination of alprazolam and oxycodone carries an FDA boxed warning for profound CNS depression, respiratory depression, and death.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Alprazolam + Morphine
                            
                        

                        
                        
Alprazolam combined with morphine carries an FDA boxed warning for serious risk of respiratory depression, sedation, coma, and death.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Alprazolam + Tramadol
                            
                        

                        
                        
Alprazolam combined with tramadol increases CNS and respiratory depression risk and may also increase seizure risk from the serotonergic interaction.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Alprazolam + Quetiapine
                            
                        

                        
                        
Co-administration of alprazolam and quetiapine produces additive CNS depression with risk of profound sedation and respiratory compromise.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Alprazolam + Diphenhydramine
                            
                        

                        
                        
Diphenhydramine adds to the sedative effects of alprazolam, increasing the risk of excessive CNS depression, falls, and cognitive impairment.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Alprazolam + Gabapentin
                            
                        

                        
                        
Alprazolam and gabapentin produce additive CNS depression, increasing the risk of sedation, dizziness, and psychomotor impairment.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Alprazolam + Cetirizine
                            
                        

                        
                        
Cetirizine has mild CNS depressant properties that can be additive with the sedative effects of alprazolam, increasing the risk of excessive sedation, psychomotor impairment, and respiratory depression.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
A benzodiazepine medication that enhances the effect of GABA, the brain's main inhibitory neurotransmitter, producing calming, anti-anxiety, and sedative effects. It is prescribed for generalized anxiety disorder, panic disorder, and anxiety associated with depression, though it carries risks of dependence and withdrawal with prolonged use.

                        

                    

                    

                    

                    
                    

                        
                        

                            
High-potency benzodiazepine GABA-A receptor modulator.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Alprazolam: Half-life: 6-12 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Alprazolam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Acetaminophen
                            Small molecule
                        
                        
                        
                            Aspirin
                            Small molecule
                        
                        
                        
                            Sertraline
                            Small molecule
                        
                        
                        
                            Escitalopram
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL661.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2118.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.