Clobazam
A benzodiazepine anticonvulsant that enhances the inhibitory neurotransmitter GABA to reduce seizure frequency, approved as an add-on therapy for Lennox-Gastaut syndrome. It also has anxiolytic properties and is used in some countries for short-term anxiety relief.
分子量
300.7400 g/mol
LogP
2.10
TPSA
40.60 Ų
リピンスキーの五則
適合
治療領域
作用機序
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …
2D構造
Cite this structure
Embed this structure
SMILES
CN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc21
InChI
InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
Molecular Formula
C16H13ClN2O2
HBD / HBA
- / 2
回転可能結合数
1
重原子数
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A benzodiazepine anticonvulsant that enhances the inhibitory neurotransmitter GABA to reduce seizure frequency, approved as an add-on therapy for Lennox-Gastaut syndrome. It also has anxiolytic properties and is used in some countries for short-term anxiety relief.
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Yes, Clobazam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL70418. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2789. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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