Ipragliflozin
This SGLT2 inhibitor works by blocking a kidney protein that reabsorbs glucose, causing excess sugar to be excreted in the urine and thereby lowering blood sugar levels in people with type 2 diabetes. It also promotes modest weight loss and blood pressure reduction.
分子量
404.5000 g/mol
LogP
2.50
TPSA
118.00 Ų
リピンスキーの五則
適合
治療領域
作用機序
Selectively inhibits sodium-glucose cotransporter 2 (SGLT2) in the proximal renal tubule, reducing glucose reabsorption and promoting urinary glucose excretion. This lowers blood glucose levels independently of insulin secretion.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively inhibits sodium-glucose cotransporter 2 (SGLT2) in the proximal renal tubule, reducing glucose reabsorption and promoting urinary glucose excretion. This lowers blood glucose levels independently of insulin secretion.
2D構造
Cite this structure
Embed this structure
SMILES
OC[C@H]1O[C@@H](c2ccc(F)c(Cc3cc4ccccc4s3)c2)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChI=1S/C21H21FO5S/c22-15-6-5-12(21-20(26)19(25)18(24)16(10-23)27-21)7-13(15)9-14-8-11-3-1-2-4-17(11)28-14/h1-8,16,18-21,23-26H,9-10H2/t16-,18-,19+,20-,21+/m1/s1
Molecular Formula
C21H21FO5S
HBD / HBA
4 / 7
回転可能結合数
4
重原子数
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
This SGLT2 inhibitor works by blocking a kidney protein that reabsorbs glucose, causing excess sugar to be excreted in the urine and thereby lowering blood sugar levels in people with type 2 diabetes. It also promotes modest weight loss and blood pressure reduction.
Selectively inhibits sodium-glucose cotransporter 2 (SGLT2) in the proximal renal tubule, reducing glucose reabsorption and promoting urinary glucose excretion. This lowers blood glucose levels independently of insulin secretion.
Yes, Ipragliflozin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2018096. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 10453870. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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