Lovastatin
A naturally occurring statin originally derived from fungus, used to lower LDL cholesterol and reduce the risk of cardiovascular events, and studied for potential anticancer and neuroprotective effects. It inhibits HMG-CoA reductase, the key enzyme in cholesterol synthesis.
分子量
404.5390 g/mol
LogP
4.30
TPSA
72.80 Ų
リピンスキーの五則
適合
治療領域
薬物分類
作用機序
First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.
2D構造
Cite this structure
Embed this structure
SMILES
CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21
InChI
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
Molecular Formula
C24H36O5
HBD / HBA
1 / 5
回転可能結合数
7
重原子数
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A naturally occurring statin originally derived from fungus, used to lower LDL cholesterol and reduce the risk of cardiovascular events, and studied for potential anticancer and neuroprotective effects. It inhibits HMG-CoA reductase, the key enzyme in cholesterol synthesis.
First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.
Key pharmacokinetic parameters for Lovastatin: Half-life: 2-3 hours.
Yes, Lovastatin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL503. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 53232. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="lovastatin"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/lovastatin/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/lovastatin/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/lovastatin/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="lovastatin"></drugfyi-drug>