Maralixibat

CHEMBL363392 Phase 4 承認済み Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

675.0 g/mol

LogP

7.1

Phase

4

An ileal bile acid transporter (IBAT) inhibitor used to treat cholestatic pruritus (severe itching) in children with progressive familial intrahepatic cholestasis (PFIC) by reducing the reabsorption of bile acids from the intestine. This helps lower bile acid levels in the blood and alleviate itching.

分子量

675.0000 g/mol

LogP

7.10

TPSA

78.50 Å²

リピンスキーの五則

不適合

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

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SMILES

CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2ccc(OCc3ccc(C[N+]45CCN(CC4)CC5)cc3)cc2)[C@H]1O

InChI

InChI=1S/C40H56N3O4S/c1-5-7-19-40(20-8-6-2)30-48(45,46)37-18-15-34(41(3)4)27-36(37)38(39(40)44)33-13-16-35(17-14-33)47-29-32-11-9-31(10-12-32)28-43-24-21-42(22-25-43)23-26-43/h9-18,27,38-39,44H,5-8,19-26,28-30H2,1-4H3/q+1/t38-,39-/m1/s1

Molecular Formula

C40H56N3O4S+

HBD / HBA

1 / 6

回転可能結合数

13

重原子数

48

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

よくある質問

An ileal bile acid transporter (IBAT) inhibitor used to treat cholestatic pruritus (severe itching) in children with progressive familial intrahepatic cholestasis (PFIC) by reducing the reabsorption of bile acids from the intestine. This helps lower bile acid levels in the blood and alleviate itching.

Yes, Maralixibat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL363392. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 9831643. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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構造

クイックデータ

分子式: C40H56N3O4S+
同義語: 1

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医学的免責事項

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.