Sodium Thiosulfate
Sodium thiosulfate is used as an antidote for cyanide poisoning (in combination with sodium nitrite or hydroxocobalamin) by acting as a sulfur donor that allows rhodanese enzyme to convert cyanide to the less toxic thiocyanate for renal excretion. It is also used to treat cisplatin-induced nephrotoxicity and ototoxicity by chelating platinum compounds, and topically for tinea versicolor and calciphylaxis. Its reactive sulfhydryl groups provide reductive detoxification of multiple cytotoxic agents.
分子量
158.1100 g/mol
TPSA
104.00 Ų
治療領域
作用機序
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
2D構造
Cite this structure
Embed this structure
SMILES
O.O.O.O.O.O=S([O-])([O-])=S.[Na+].[Na+]
InChI
InChI=1S/2Na.H2O3S2.5H2O/c;;1-5(2,3)4;;;;;/h;;(H2,1,2,3,4);5*1H2/q2*+1;;;;;;/p-2
Molecular Formula
Na2O3S2
HBD / HBA
- / 4
回転可能結合数
0
重原子数
7
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Sodium thiosulfate is used as an antidote for cyanide poisoning (in combination with sodium nitrite or hydroxocobalamin) by acting as a sulfur donor that allows rhodanese enzyme to convert cyanide to the less toxic thiocyanate for renal excretion. It is also used to treat cisplatin-induced nephrotoxicity and ototoxicity by chelating platinum compounds, and topically for tinea versicolor and calciphylaxis. Its reactive sulfhydryl groups provide reductive detoxification of multiple cytotoxic agents.
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Yes, Sodium Thiosulfate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2096650. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 24477. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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