Sulfaphenazole
Sulfaphenazole is a sulfonamide antibacterial and potent inhibitor of cytochrome P450 2C9 (CYP2C9), used primarily as a research tool to characterize CYP2C9-mediated drug metabolism, and historically as an antibacterial agent for urinary tract infections. Its CYP2C9 inhibition causes clinically significant interactions with drugs metabolized by this enzyme including warfarin, tolbutamide, and phenytoin. The antibacterial mechanism involves inhibition of dihydropteroate synthase.
分子量
314.4000 g/mol
LogP
1.50
TPSA
98.40 Ų
リピンスキーの五則
適合
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D構造
Cite this structure
Embed this structure
SMILES
Nc1ccc(S(=O)(=O)Nc2ccnn2-c2ccccc2)cc1
InChI
InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
Molecular Formula
C15H14N4O2S
HBD / HBA
2 / 5
回転可能結合数
4
重原子数
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Sulfaphenazole is a sulfonamide antibacterial and potent inhibitor of cytochrome P450 2C9 (CYP2C9), used primarily as a research tool to characterize CYP2C9-mediated drug metabolism, and historically as an antibacterial agent for urinary tract infections. Its CYP2C9 inhibition causes clinically significant interactions with drugs metabolized by this enzyme including warfarin, tolbutamide, and phenytoin. The antibacterial mechanism involves inhibition of dihydropteroate synthase.
Yes, Sulfaphenazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1109. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5335. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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