Enzyme Target
An enzyme whose catalytic activity is modulated by a drug to produce a therapeutic effect. Enzyme inhibitors can be reversible (competitive, uncompetitive, noncompetitive) or irreversible (covalent). Approximately 29% of approved drugs target enzymes, making them the second-largest target class after GPCRs.
例
- ACE inhibited by lisinopril (hypertension)
- COX-2 inhibited by celecoxib (inflammation)
- HIV protease inhibited by ritonavir (HIV/AIDS)
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An enzyme whose catalytic activity is modulated by a drug to produce a therapeutic effect. Enzyme inhibitors can be reversible (competitive, uncompetitive, noncompetitive) or irreversible (covalent). Approximately 29% of approved …