Loading Dose
An initial higher dose given to rapidly achieve therapeutic plasma concentrations before steady state. Calculated as Vd * target concentration / bioavailability.
例
- Digoxin 0.5-1mg loading
- Amiodarone IV loading
- Phenytoin 15-20mg/kg loading
ご存知でしたか？
An initial higher dose given to rapidly achieve therapeutic plasma concentrations before steady state. Calculated as Vd * target concentration / bioavailability.