Selectivity
The ability of a drug to preferentially act on a specific receptor subtype, tissue, or organ. Higher selectivity generally means fewer off-target effects. Expressed as the ratio of binding affinities.
例
- Beta-1 selective: metoprolol, atenolol
- COX-2 selective: celecoxib
- SSRI selectivity for SERT
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The ability of a drug to preferentially act on a specific receptor subtype, tissue, or organ. Higher selectivity generally means fewer off-target effects. Expressed as the ratio of binding affinities.