DRD2 (Dopamine D2 Receptor)
DRD2
G-protein coupled receptor (Gi/o) mediating dopaminergic neurotransmission.
機能
Key target for antipsychotic drugs (antagonists) and anti-parkinsonian agents (agonists). D2 blockade in the mesolimbic pathway reduces positive psychotic symptoms.
この標的に作用する薬物
| 薬物 | 作用 | 主要 |
|---|---|---|
| Levodopa | Agonist | はい |
| Quetiapine | Antagonist | はい |
| Aripiprazole | Partial Agonist | はい |
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OPRM1 (Mu-Opioid Receptor)
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PDCD1 (Programmed Cell Death Protein 1)
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SIGMAR1 (Sigma-1 Receptor)
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AGTR1 (Angiotensin II Type 1 Receptor)
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CTLA4 (Cytotoxic T-Lymphocyte Antigen 4)
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ADRB1 (Beta-1 Adrenergic Receptor)
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ADRB2 (Beta-2 Adrenergic Receptor)
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HRH2 (Histamine H2 Receptor)
HRH2