DRD2 (Dopamine D2 Receptor)
DRD2
G-protein coupled receptor (Gi/o) mediating dopaminergic neurotransmission.
Function
Key target for antipsychotic drugs (antagonists) and anti-parkinsonian agents (agonists). D2 blockade in the mesolimbic pathway reduces positive psychotic symptoms.
Drugs Acting on This Target
| Drug | Action | Primary |
|---|---|---|
| Levodopa | Agonist | Yes |
| Quetiapine | Antagonist | Yes |
| Aripiprazole | Partial Agonist | Yes |
Related Targets
AGTR1 (Angiotensin II Type 1 Receptor)
AGTR1
ADRB1 (Beta-1 Adrenergic Receptor)
ADRB1
ADRB2 (Beta-2 Adrenergic Receptor)
ADRB2
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4)
CTLA4
HRH1 (Histamine H1 Receptor)
HRH1
HRH2 (Histamine H2 Receptor)
HRH2
OPRM1 (Mu-Opioid Receptor)
OPRM1
PDCD1 (Programmed Cell Death Protein 1)
PDCD1