CTLA4 (Cytotoxic T-Lymphocyte Antigen 4)
CTLA4
Immune checkpoint receptor that negatively regulates T cell activation at the priming stage.
Function
CTLA-4 blockade (ipilimumab) enhances T cell activation. First checkpoint inhibitor approved for melanoma.
Drugs Acting on This Target
| Drug | Action | Primary |
|---|---|---|
| Pembrolizumab | Other | — |
Related Targets
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ADRB1 (Beta-1 Adrenergic Receptor)
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DRD2 (Dopamine D2 Receptor)
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HRH1 (Histamine H1 Receptor)
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HRH2 (Histamine H2 Receptor)
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PDCD1 (Programmed Cell Death Protein 1)
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