HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
機能
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
この標的に作用する薬物
| 薬物 | 作用 | 主要 |
|---|---|---|
| Atorvastatin | Inhibitor | はい |
| Simvastatin | Inhibitor | はい |
| Rosuvastatin | Inhibitor | はい |
| Pravastatin | Inhibitor | はい |