Amenamevir
An antiviral medication that inhibits the helicase-primase enzyme complex essential for herpesvirus DNA replication, offering a different mechanism of action from nucleoside analogues like acyclovir. It is approved in Japan for treating herpes zoster (shingles) and may be effective in patients with acyclovir-resistant herpesvirus infections.
분자량
482.6000 g/mol
LogP
2.60
TPSA
131.00 Ų
리핀스키 5의 법칙
통과
작용 기전
Incorporated into viral DNA by reverse transcriptase as a nucleoside analog, causing chain termination and inhibition of viral replication.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Incorporated into viral DNA by reverse transcriptase as a nucleoside analog, causing chain termination and inhibition of viral replication.
2D 구조
Cite this structure
Embed this structure
SMILES
Cc1cccc(C)c1N(CC(=O)Nc1ccc(-c2ncon2)cc1)C(=O)C1CCS(=O)(=O)CC1
InChI
InChI=1S/C24H26N4O5S/c1-16-4-3-5-17(2)22(16)28(24(30)19-10-12-34(31,32)13-11-19)14-21(29)26-20-8-6-18(7-9-20)23-25-15-33-27-23/h3-9,15,19H,10-14H2,1-2H3,(H,26,29)
Molecular Formula
C24H26N4O5S
HBD / HBA
1 / 7
회전 가능 결합
6
무거운 원자
34
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
자주 묻는 질문
An antiviral medication that inhibits the helicase-primase enzyme complex essential for herpesvirus DNA replication, offering a different mechanism of action from nucleoside analogues like acyclovir. It is approved in Japan for treating herpes zoster (shingles) and may be effective in patients with acyclovir-resistant herpesvirus infections.
Incorporated into viral DNA by reverse transcriptase as a nucleoside analog, causing chain termination and inhibition of viral replication.
Yes, Amenamevir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297592. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11397521. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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