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Picosulfuric Acid

CHEMBL1741134 Phase 4 승인됨 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
437.4 g/mol
LogP
2.4
Phase
4

Picosulfuric acid (sodium picosulfate) is a stimulant laxative prodrug that is converted by colonic bacteria to its active form, which directly stimulates the enteric nerve plexus of the colon to increase peristalsis while also softening the stool by reducing water and electrolyte absorption. It is used for the treatment of constipation and as a bowel preparation agent prior to colonoscopy or surgery.

분자량

437.4000 g/mol

LogP

2.40

TPSA

157.00 Ų

리핀스키 5의 법칙

통과

작용 기전

Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

기전

Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.

2D 구조

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=S(=O)(O)Oc1ccc(C(c2ccc(OS(=O)(=O)O)cc2)c2ccccn2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C18H15NO8S2/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25/h1-12,18H,(H,20,21,22)(H,23,24,25)

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H15NO8S2

                    

                    
                    

                        
HBD / HBA

                        
2 / 9

                    

                    
                    

                        
회전 가능 결합

                        
7

                    

                    
                    
                    

                        
무거운 원자

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
자주 묻는 질문

                

                    
                    

                        
                        

                            
Picosulfuric acid (sodium picosulfate) is a stimulant laxative prodrug that is converted by colonic bacteria to its active form, which directly stimulates the enteric nerve plexus of the colon to increase peristalsis while also softening the stool by reducing water and electrolyte absorption. It is used for the treatment of constipation and as a bowel preparation agent prior to colonoscopy or surgery.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Picosulfuric Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1741134.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5243.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
의학적 면책조항

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.