Picosulfuric Acid
Picosulfuric acid (sodium picosulfate) is a stimulant laxative prodrug that is converted by colonic bacteria to its active form, which directly stimulates the enteric nerve plexus of the colon to increase peristalsis while also softening the stool by reducing water and electrolyte absorption. It is used for the treatment of constipation and as a bowel preparation agent prior to colonoscopy or surgery.
Peso Molecular
437,4000 g/mol
LogP
2,40
TPSA
157,00 Ų
Regra dos 5 de Lipinski
Aprovado
Mecanismo de Ação
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
O=S(=O)(O)Oc1ccc(C(c2ccc(OS(=O)(=O)O)cc2)c2ccccn2)cc1
InChI
InChI=1S/C18H15NO8S2/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25/h1-12,18H,(H,20,21,22)(H,23,24,25)
Molecular Formula
C18H15NO8S2
HBD / HBA
2 / 9
Ligações Rotacionáveis
7
Átomos Pesados
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Picosulfuric acid (sodium picosulfate) is a stimulant laxative prodrug that is converted by colonic bacteria to its active form, which directly stimulates the enteric nerve plexus of the colon to increase peristalsis while also softening the stool by reducing water and electrolyte absorption. It is used for the treatment of constipation and as a bowel preparation agent prior to colonoscopy or surgery.
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.
Yes, Picosulfuric Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1741134. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5243. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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