Inverse Agonist
A ligand that binds to the same receptor as an agonist but produces the opposite pharmacological effect by reducing constitutive (basal) receptor activity below baseline.
예시
- Some antihistamines at H1 receptor
- Beta-carbolines at GABA-A
- Rimonabant at CB1
알고 계셨나요?
A ligand that binds to the same receptor as an agonist but produces the opposite pharmacological effect by reducing constitutive (basal) receptor activity below baseline.