Inverse Agonist
A ligand that binds to the same receptor as an agonist but produces the opposite pharmacological effect by reducing constitutive (basal) receptor activity below baseline.
Ví dụ
- Some antihistamines at H1 receptor
- Beta-carbolines at GABA-A
- Rimonabant at CB1
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A ligand that binds to the same receptor as an agonist but produces the opposite pharmacological effect by reducing constitutive (basal) receptor activity below baseline.