Major
Probable
설명
Azithromycin and quetiapine both prolong the QT interval via hERG blockade; concurrent use significantly increases the risk of life-threatening arrhythmias.
기전
Additive hERG (IKr) potassium channel blockade prolongs ventricular repolarization; azithromycin also inhibits CYP3A4 modestly, potentially increasing quetiapine exposure.
임상적 중요성
Multiple case reports and pharmacovigilance data document torsades de pointes with this combination.
관리 방법
Avoid combination; use alternative antibiotics (e.g., amoxicillin) when possible; if unavoidable, obtain ECG and correct electrolytes.