Besifloxacin
A broad-spectrum fluoroquinolone antibiotic formulated exclusively as eye drops to treat bacterial conjunctivitis. It works by inhibiting bacterial enzymes needed for DNA replication and repair. Because it is not available in systemic forms, resistance development is considered lower risk.
Peso Molecular
393,8000 g/mol
LogP
1,10
TPSA
86,90 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
N[C@@H]1CCCCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1
InChI
InChI=1S/C19H21ClFN3O3/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23/h7,9-11H,1-6,8,22H2,(H,26,27)/t10-/m1/s1
Molecular Formula
C19H21ClFN3O3
HBD / HBA
2 / 7
Ligações Rotacionáveis
3
Átomos Pesados
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A broad-spectrum fluoroquinolone antibiotic formulated exclusively as eye drops to treat bacterial conjunctivitis. It works by inhibiting bacterial enzymes needed for DNA replication and repair. Because it is not available in systemic forms, resistance development is considered lower risk.
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Yes, Besifloxacin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201760. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 10178705. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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