Carboprost Tromethamine
The tromethamine salt of carboprost is administered intramuscularly to treat postpartum hemorrhage caused by uterine atony that has not responded to conventional management. As a prostaglandin F2α analog, it potently stimulates myometrial contractions. It is contraindicated in patients with active cardiac, pulmonary, renal, or hepatic disease.
Peso Molecular
489,6000 g/mol
TPSA
185,00 Ų
Mecanismo de Ação
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CCCCC[C@](C)(O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)[C@@H](O)C[C@H]1O.NC(CO)(CO)CO
InChI
InChI=1S/C21H36O5.C4H11NO3/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25;5-4(1-6,2-7)3-8/h5,7,12,14,16-19,22-23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25);6-8H,1-3,5H2/b7-5-,14-12+;/t16-,17-,18+,19-,21+;/m1./s1
Molecular Formula
C25H47NO8
HBD / HBA
8 / 9
Ligações Rotacionáveis
15
Átomos Pesados
34
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
The tromethamine salt of carboprost is administered intramuscularly to treat postpartum hemorrhage caused by uterine atony that has not responded to conventional management. As a prostaglandin F2α analog, it potently stimulates myometrial contractions. It is contraindicated in patients with active cardiac, pulmonary, renal, or hepatic disease.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Carboprost Tromethamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1237105. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5281074. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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