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Cefepime

CHEMBL186 Phase 4 Aprovado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
480.6 g/mol
LogP
-0.1
Phase
4

A fourth-generation cephalosporin antibiotic that covers a broad spectrum of gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa. It is used for serious hospital-acquired infections such as pneumonia, bacteremia, and febrile neutropenia. Neurotoxicity, including encephalopathy and seizures, has been reported, particularly in patients with renal impairment.

Peso Molecular

480,6000 g/mol

LogP

-0,10

TPSA

204,00 Ų

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Pain Management Asthma Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Infectious Disease Chronic Kidney Disease Lymphoma Hypertension Breast Cancer Chronic Pain Heart Failure Leukemia

Mecanismo de Ação

Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

Estrutura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[N+]3(C)CCCC3)CS[C@H]12)c1csc(N)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H24N6O5S2

                    

                    
                    

                        
HBD / HBA

                        
2 / 10

                    

                    
                    

                        
Ligações Rotacionáveis

                        
6

                    

                    
                    
                    

                        
Átomos Pesados

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
A fourth-generation cephalosporin antibiotic that covers a broad spectrum of gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa. It is used for serious hospital-acquired infections such as pneumonia, bacteremia, and febrile neutropenia. Neurotoxicity, including encephalopathy and seizures, has been reported, particularly in patients with renal impairment.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Cefepime is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL186.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5479537.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.