Chlordiazepoxide
A long-acting benzodiazepine that enhances the effect of the inhibitory neurotransmitter GABA, producing anxiolytic, sedative, and muscle relaxant effects. It is used to treat anxiety disorders and is a first-line agent for the management of alcohol withdrawal syndrome due to its long duration of action. Long-term use can lead to tolerance and physical dependence.
Peso Molecular
299,7500 g/mol
LogP
2,40
TPSA
48,20 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C1
InChI
InChI=1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
Molecular Formula
C16H14ClN3O
HBD / HBA
1 / 3
Ligações Rotacionáveis
1
Átomos Pesados
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A long-acting benzodiazepine that enhances the effect of the inhibitory neurotransmitter GABA, producing anxiolytic, sedative, and muscle relaxant effects. It is used to treat anxiety disorders and is a first-line agent for the management of alcohol withdrawal syndrome due to its long duration of action. Long-term use can lead to tolerance and physical dependence.
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Yes, Chlordiazepoxide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL451. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2712. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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