Dasatinib
An oral BCR-ABL and Src family kinase inhibitor used to treat chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, including some cases resistant to imatinib. It also inhibits the Src kinase family, which may contribute to additional antitumor effects.
Peso Molecular
488,0000 g/mol
LogP
3,60
TPSA
135,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Inhibits the BCR-ABL fusion tyrosine kinase, the constitutively active oncoprotein responsible for driving chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits the BCR-ABL fusion tyrosine kinase, the constitutively active oncoprotein responsible for driving chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O
InChI
InChI=1S/C22H26ClN7O2S.H2O/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31;/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27);1H2
Molecular Formula
C22H26ClN7O2S
HBD / HBA
3 / 9
Ligações Rotacionáveis
7
Átomos Pesados
33
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
An oral BCR-ABL and Src family kinase inhibitor used to treat chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, including some cases resistant to imatinib. It also inhibits the Src kinase family, which may contribute to additional antitumor effects.
Inhibits the BCR-ABL fusion tyrosine kinase, the constitutively active oncoprotein responsible for driving chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.
Yes, Dasatinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5416410. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3062316. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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