Dextrothyroxine

CHEMBL559 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

776.9 g/mol

LogP

2.4

Phase

4

The d-isomer of thyroxine (T4) that was used as a lipid-lowering agent in the 1960s but was withdrawn after clinical trials showed increased cardiovascular events and mortality. It lowered LDL cholesterol but caused thyrotoxicosis and other harmful effects.

Peso Molecular

776,8700 g/mol

LogP

2,40

TPSA

92,80 Å²

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Cardiovascular Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

SVG PNG

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SMILES

N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O

InChI

InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1

Molecular Formula

C15H11I4NO4

HBD / HBA

3 / 5

Ligações Rotacionáveis

5

Átomos Pesados

24

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

The d-isomer of thyroxine (T4) that was used as a lipid-lowering agent in the 1960s but was withdrawn after clinical trials showed increased cardiovascular events and mortality. It lowered LDL cholesterol but caused thyrotoxicosis and other harmful effects.

Yes, Dextrothyroxine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL559. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 8730. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

PillFYI

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Dextrothyroxine no PillFYI

Estrutura

Dados Rápidos

Fórmula: C15H11I4NO4

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.