Guanethidine Monosulfate

CHEMBL1345 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

296.4 g/mol

LogP

—

Phase

4

A monosulfate salt form of guanethidine, an antihypertensive that blocks norepinephrine release from sympathetic neurons to lower blood pressure in patients with difficult-to-control hypertension. This salt form is the pharmaceutical preparation used in clinical practice. Its use requires careful management of orthostatic hypotension and drug interactions.

Peso Molecular

296,3900 g/mol

TPSA

151,00 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

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SMILES

N=C(N)NCCN1CCCCCCC1.O=S(=O)(O)O

InChI

InChI=1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)

Molecular Formula

C10H24N4O4S

HBD / HBA

4 / 6

Ligações Rotacionáveis

3

Átomos Pesados

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

A monosulfate salt form of guanethidine, an antihypertensive that blocks norepinephrine release from sympathetic neurons to lower blood pressure in patients with difficult-to-control hypertension. This salt form is the pharmaceutical preparation used in clinical practice. Its use requires careful management of orthostatic hypotension and drug interactions.

Yes, Guanethidine Monosulfate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1345. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 86471. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

PillFYI

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Estrutura

Dados Rápidos

Fórmula: C10H24N4O4S

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.