Isosulfan Blue
This blue dye is injected near tumors during surgery to trace the lymphatic drainage pathway and identify sentinel lymph nodes, which are the first nodes most likely to contain cancer cells if the tumor has spread. Surgeons use this mapping technique to determine whether cancer has metastasized without removing all nearby lymph nodes.
Peso Molecular
566,7000 g/mol
TPSA
137,00 Ų
Áreas Terapêuticas
Mecanismo de Ação
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2cc(S(=O)(=O)[O-])ccc2S(=O)(=O)[O-])cc1.[Na+]
InChI
InChI=1S/C27H32N2O6S2.Na/c1-5-28(6-2)22-13-9-20(10-14-22)27(21-11-15-23(16-12-21)29(7-3)8-4)25-19-24(36(30,31)32)17-18-26(25)37(33,34)35;/h9-19H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1
Molecular Formula
C27H31N2NaO6S2
HBD / HBA
- / 7
Ligações Rotacionáveis
7
Átomos Pesados
38
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
This blue dye is injected near tumors during surgery to trace the lymphatic drainage pathway and identify sentinel lymph nodes, which are the first nodes most likely to contain cancer cells if the tumor has spread. Surgeons use this mapping technique to determine whether cancer has metastasized without removing all nearby lymph nodes.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Isosulfan Blue is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200859. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 50108. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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