Phensuximide

CHEMBL797 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

189.2 g/mol

LogP

0.8

Phase

4

Phensuximide is an anticonvulsant of the succinimide class that reduces absence seizures by inhibiting T-type calcium channels in thalamic neurons, thereby suppressing the rhythmic thalamocortical discharges responsible for absence seizure activity. It is used as an alternative to ethosuximide in the management of absence (petit mal) epilepsy, though it is considered less effective and more toxic.

Peso Molecular

189,2100 g/mol

LogP

0,80

TPSA

37,40 Å²

Regra dos 5 de Lipinski

Aprovado

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

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SMILES

CN1C(=O)CC(c2ccccc2)C1=O

InChI

InChI=1S/C11H11NO2/c1-12-10(13)7-9(11(12)14)8-5-3-2-4-6-8/h2-6,9H,7H2,1H3

Molecular Formula

C11H11NO2

HBD / HBA

- / 2

Ligações Rotacionáveis

1

Átomos Pesados

14

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

Phensuximide is an anticonvulsant of the succinimide class that reduces absence seizures by inhibiting T-type calcium channels in thalamic neurons, thereby suppressing the rhythmic thalamocortical discharges responsible for absence seizure activity. It is used as an alternative to ethosuximide in the management of absence (petit mal) epilepsy, though it is considered less effective and more toxic.

Yes, Phensuximide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL797. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6839. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Estrutura

Dados Rápidos

Fórmula: C11H11NO2

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.