Sorafenib
This multi-targeted oral kinase inhibitor blocks several proteins that cancer cells use to grow new blood vessels and divide, effectively cutting off tumor blood supply and directly slowing cancer cell proliferation. It is approved for liver, kidney, and thyroid cancers and is studied in bladder and breast cancers.
Peso Molecular
464,8000 g/mol
LogP
4,10
TPSA
92,40 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1
InChI
InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
Molecular Formula
C21H16ClF3N4O3
HBD / HBA
3 / 7
Ligações Rotacionáveis
5
Átomos Pesados
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
This multi-targeted oral kinase inhibitor blocks several proteins that cancer cells use to grow new blood vessels and divide, effectively cutting off tumor blood supply and directly slowing cancer cell proliferation. It is approved for liver, kidney, and thyroid cancers and is studied in bladder and breast cancers.
Yes, Sorafenib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1336. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 216239. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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