Sparsentan
Sparsentan is a dual angiotensin II AT1 receptor and endothelin A receptor antagonist developed for the treatment of IgA nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS). By simultaneously blocking both the renin-angiotensin and endothelin pathways contributing to glomerular hypertension, proteinuria, and progressive renal fibrosis, it provides complementary nephroprotective effects beyond what is achievable with either pathway blockade alone. It has demonstrated significant reductions in proteinuria in clinical trials.
Peso Molecular
592,8000 g/mol
LogP
5,00
TPSA
122,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2noc(C)c2C)c(COCC)c1
InChI
InChI=1S/C32H40N4O5S/c1-5-7-14-29-33-32(17-10-11-18-32)31(37)36(29)20-24-15-16-26(25(19-24)21-40-6-2)27-12-8-9-13-28(27)42(38,39)35-30-22(3)23(4)41-34-30/h8-9,12-13,15-16,19H,5-7,10-11,14,17-18,20-21H2,1-4H3,(H,34,35)
Molecular Formula
C32H40N4O5S
HBD / HBA
1 / 8
Ligações Rotacionáveis
12
Átomos Pesados
42
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Sparsentan is a dual angiotensin II AT1 receptor and endothelin A receptor antagonist developed for the treatment of IgA nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS). By simultaneously blocking both the renin-angiotensin and endothelin pathways contributing to glomerular hypertension, proteinuria, and progressive renal fibrosis, it provides complementary nephroprotective effects beyond what is achievable with either pathway blockade alone. It has demonstrated significant reductions in proteinuria in clinical trials.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Sparsentan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL539423. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 10257882. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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