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Sparsentan

CHEMBL539423 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
592.8 g/mol
LogP
5.0
Phase
4

Sparsentan is a dual angiotensin II AT1 receptor and endothelin A receptor antagonist developed for the treatment of IgA nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS). By simultaneously blocking both the renin-angiotensin and endothelin pathways contributing to glomerular hypertension, proteinuria, and progressive renal fibrosis, it provides complementary nephroprotective effects beyond what is achievable with either pathway blockade alone. It has demonstrated significant reductions in proteinuria in clinical trials.

น้ำหนักโมเลกุล

592.8000 g/mol

LogP

5.00

TPSA

122.00 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Cardiovascular Disease

กลไกการออกฤทธิ์

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2noc(C)c2C)c(COCC)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C32H40N4O5S/c1-5-7-14-29-33-32(17-10-11-18-32)31(37)36(29)20-24-15-16-26(25(19-24)21-40-6-2)27-12-8-9-13-28(27)42(38,39)35-30-22(3)23(4)41-34-30/h8-9,12-13,15-16,19H,5-7,10-11,14,17-18,20-21H2,1-4H3,(H,34,35)

                

                

                

                    
                    

                        
Molecular Formula

                        
C32H40N4O5S

                    

                    
                    

                        
HBD / HBA

                        
1 / 8

                    

                    
                    

                        
พันธะที่หมุนได้

                        
12

                    

                    
                    
                    

                        
อะตอมหนัก

                        
42

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Sparsentan is a dual angiotensin II AT1 receptor and endothelin A receptor antagonist developed for the treatment of IgA nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS). By simultaneously blocking both the renin-angiotensin and endothelin pathways contributing to glomerular hypertension, proteinuria, and progressive renal fibrosis, it provides complementary nephroprotective effects beyond what is achievable with either pathway blockade alone. It has demonstrated significant reductions in proteinuria in clinical trials.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Sparsentan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL539423.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 10257882.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.