Tridihexethyl
Tridihexethyl is a quaternary ammonium anticholinergic agent that competitively blocks muscarinic acetylcholine receptors in smooth muscle, exocrine glands, and the CNS, reducing gastrointestinal motility and secretions for the treatment of peptic ulcer disease, irritable bowel syndrome, and functional gastrointestinal disorders. As a quaternary ammonium compound, it has limited CNS penetration, reducing central anticholinergic adverse effects compared to tertiary amine anticholinergics. Its primary effects are on peripheral muscarinic receptors in the GI tract.
Peso Molecular
318,5000 g/mol
LogP
4,80
TPSA
20,20 Ų
Regra dos 5 de Lipinski
Aprovado
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1
InChI
InChI=1S/C21H36NO/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3/q+1
Molecular Formula
C21H36NO+
HBD / HBA
1 / 1
Ligações Rotacionáveis
8
Átomos Pesados
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Tridihexethyl is a quaternary ammonium anticholinergic agent that competitively blocks muscarinic acetylcholine receptors in smooth muscle, exocrine glands, and the CNS, reducing gastrointestinal motility and secretions for the treatment of peptic ulcer disease, irritable bowel syndrome, and functional gastrointestinal disorders. As a quaternary ammonium compound, it has limited CNS penetration, reducing central anticholinergic adverse effects compared to tertiary amine anticholinergics. Its primary effects are on peripheral muscarinic receptors in the GI tract.
Yes, Tridihexethyl is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201354. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 20299. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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