Vibegron
Vibegron is a selective beta-3 adrenergic receptor agonist that activates β3 receptors in bladder smooth muscle (detrusor), causing relaxation and increasing bladder capacity while reducing urinary urgency and frequency without affecting bladder contractility during voiding. It is approved for overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency in adults. As a β3 agonist, it offers an alternative mechanism to antimuscarinics with potentially fewer systemic anticholinergic side effects.
Peso Molecular
444,5000 g/mol
LogP
1,80
TPSA
94,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
O=C(Nc1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)[C@@H]1CCc2nccc(=O)n21
InChI
InChI=1S/C26H28N4O3/c31-24-14-15-27-23-13-12-22(30(23)24)26(33)29-19-8-6-17(7-9-19)16-20-10-11-21(28-20)25(32)18-4-2-1-3-5-18/h1-9,14-15,20-22,25,28,32H,10-13,16H2,(H,29,33)/t20-,21+,22-,25+/m0/s1
Molecular Formula
C26H28N4O3
HBD / HBA
3 / 5
Ligações Rotacionáveis
6
Átomos Pesados
33
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Vibegron is a selective beta-3 adrenergic receptor agonist that activates β3 receptors in bladder smooth muscle (detrusor), causing relaxation and increasing bladder capacity while reducing urinary urgency and frequency without affecting bladder contractility during voiding. It is approved for overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency in adults. As a β3 agonist, it offers an alternative mechanism to antimuscarinics with potentially fewer systemic anticholinergic side effects.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Vibegron is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2107826. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 44472635. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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