Voclosporin

CHEMBL5314379 Phase 4 Aprovado Protein

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

1214.6 g/mol

LogP

7.9

Phase

4

Voclosporin is a novel calcineurin inhibitor structurally related to cyclosporine that suppresses T-cell activation by blocking calcineurin-mediated dephosphorylation of NFAT transcription factors, thereby reducing IL-2 production and T-cell proliferation in immune-mediated diseases. It is approved for the treatment of adult patients with active lupus nephritis in combination with immunosuppressive background therapy. Compared to cyclosporine, voclosporin has a more predictable pharmacokinetic profile and additional podocyte-stabilizing effects.

Peso Molecular

1214,6000 g/mol

LogP

7,90

TPSA

279,00 Å²

Regra dos 5 de Lipinski

Reprovado

Áreas Terapêuticas

Psoriasis Systemic Lupus Erythematosus

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

SVG PNG

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SMILES

C=C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C

InChI

InChI=1S/C63H111N11O12/c1-25-27-28-29-41(15)53(76)52-57(80)66-44(26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27-28,35-48,50-53,76H,1,26,29-34H2,2-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b28-27+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/m1/s1

Molecular Formula

C63H111N11O12

HBD / HBA

5 / 12

Ligações Rotacionáveis

16

Átomos Pesados

86

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

Voclosporin is a novel calcineurin inhibitor structurally related to cyclosporine that suppresses T-cell activation by blocking calcineurin-mediated dephosphorylation of NFAT transcription factors, thereby reducing IL-2 production and T-cell proliferation in immune-mediated diseases. It is approved for the treatment of adult patients with active lupus nephritis in combination with immunosuppressive background therapy. Compared to cyclosporine, voclosporin has a more predictable pharmacokinetic profile and additional podocyte-stabilizing effects.

Yes, Voclosporin is an approved drug. It has reached clinical phase 4. It is classified as a Protein.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5314379. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6918486. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Estrutura

Dados Rápidos

Fórmula: C63H111N11O12
Sinônimos: 1

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.